Pregnenolone-d4

• Description :

  Pregnenolone-d4 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

• Product Name Alternative :

  3β-Hydroxy-5-pregnen-20-one-d4

• UNSPSC :

  12352211

• Target :

  Autophagy; Cannabinoid Receptor; Endogenous Metabolite; Isotope-Labeled Compounds; TRP Channel

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Purity :

  0.9783

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@](C1=CC2)(CC([2H])([2H])[C@H](O)C1([2H])[2H])[C@]3([H])[C@]2([H])[C@@](CC[C@@H]4C(C)=O)([H])[C@]4(C)CC3

• Molecular Formula :

  C21H28D4O2

• Molecular Weight :

  320.50

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343 (6166) :94-8.|[3]Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14 (1) :7.|[4]Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641 (2-3) :128-34.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported