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Glimepiride-d4-1

CAT: 0804-HY-B0104S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0104S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glimepiride-d4-1 is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
CAS Number
1131981-29-7
Product Name Alternative
Glimperide-d4; HOE-490-d4
UNSPSC
12352005
Target
Amyloid-β; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.39
Solubility
10 mM in DMSO
Smiles
C[C@H](CC1)CC[C@@H]1NC(NS(C(C=C2)=CC=C2C([2H])([2H])C([2H])([2H])NC(N3C(C(CC)=C(C3)C)=O)=O)(=O)=O)=O
Molecular Formula
C24H30D4N4O5S
Molecular Weight
494.64
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS) . [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.|[3]Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38 (8) : p. 1120-30.|[4]Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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CS-O-02884Glimepiride-d4
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