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Glimepiride-d5

CAT: 0804-HY-B0104SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0104SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glimepiride-d5 is the deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
CAS Number
1028809-90-6
UNSPSC
12352005
Hazard Statement
H319-H360
Target
Amyloid-β; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
C[C@H](CC1)CC[C@@H]1NC(NS(C(C=C2)=CC=C2CCNC(N3C(C(C([2H])([2H])C([2H])([2H])[2H])=C(C3)C)=O)=O)(=O)=O)=O
Molecular Formula
C24H29D5N4O5S
Molecular Weight
495.65
Precautions
P264-P280-P305+P351+P338-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38 (8) : p. 1120-30.|[3]Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4.|[4]Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS) . [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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