Flutamide-d7

CAT: 0804-HY-B0022SSize: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-B0022SSize:500 µg
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Description
Flutamide-d7 is deuterium labeled Flutamide.
CAS Number
[223134-72-3]
Product Name Alternative
SCH 13521-d7
UNSPSC
12352005
Hazard Statement
H302+H312+H332-H315-H319-H361
Target
Androgen Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C11H4D7F3N2O3
Molecular Weight
283.25
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321 (7) :419-24.|[3]Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31 (5) :845-52.|[4]Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29 (6) :691-8.|[5]Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44 (3) :261-70.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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