Flutamide-d7

• Description :

  Flutamide-d7 is deuterium labeled Flutamide.

• Product Name Alternative :

  SCH 13521-d7

• UNSPSC :

  12352005

• Hazard Statement :

  H302+H312+H332-H315-H319-H361

• Target :

  Androgen Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Others; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

• Molecular Formula :

  C11H4D7F3N2O3

• Molecular Weight :

  283.25

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P405-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321 (7) :419-24.|[3]Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31 (5) :845-52.|[4]Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29 (6) :691-8.|[5]Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44 (3) :261-70.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [223134-72-3]