Roslin 2 (bromide)

• Description :

  Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

• Product Name Alternative :

  Benzylhexamethylenetetramine (bromide)

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  FAK; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/roslin-2-bromide.html

• Purity :

  99.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  [N@@]12C[N+](C[N@](C3)C1)(C[N@@]3C2)CC4=CC=CC=C4.[Br-]

• Molecular Formula :

  C13H19BrN4

• Molecular Weight :

  311.22

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [29574-21-8]