Roslin 2 (bromide)

• UNSPSC Description:

  Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

• Target Antigen:

  FAK; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/roslin-2-bromide.html

• Purity:

  99.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  [N@@]12C[N+](C[N@](C3)C1)(C[N@@]3C2)CC4=CC=CC=C4.[Br-]

• Molecular Weight:

  311.22

• References & Citations:

  [1]Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  29574-21-8