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Zuclopenthixol (dihydrochloride)

CAT: 0804-HY-A0163BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0163BSize:1 Each
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Description
Zuclopenthixol ((Z) -Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia[1][2][3].
CAS Number
58045-23-1
Product Name Alternative
(Z) -Clopenthixol (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zuclopenthixol-dihydrochloride.html
Purity
99.98
Solubility
10 mM in DMSO
Smiles
ClC1=CC2=C(C=C1)SC3=C(C=CC=C3)/C2=C/CCN4CCN(CC4)CCO.[H]Cl.[H]Cl
Molecular Formula
C22H27Cl3N2OS
Molecular Weight
473.89
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23 (9) :439-45. |[2]Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21 (1) :11-5. |[3]Bryan EJ, et al. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev. 2017 Nov 16;11 (11) :CD005474.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor

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