Zuclopenthixol

• Description :

  Zuclopenthixol ((Z) -Clopenthixol) is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].

• Product Name Alternative :

  (Z) -Clopenthixol

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Zuclopenthixol.html

• Purity :

  98.08

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  OCCN1CCN(CC/C=C2C3=C(SC4=C\2C=CC=C4)C=CC(Cl)=C3)CC1

• Molecular Formula :

  C22H25ClN2OS

• Molecular Weight :

  400.96

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21 (1) :11-5.|[2]Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23 (9) :439-45.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  D2 Receptor

• CAS Number :

  [53772-83-1]