N-Boc-D-prolinol

• Description :

  N-Boc-D-prolinol is a protected chiral proline derivative. N-Boc-D-prolinol facilitates the synthesis of highly selective histamine H1 and H3 receptor antagonists. N-Boc-D-prolinol can be used in the research of allergic rhinitis[1][2].

• CAS Number :

  [83435-58-9]

• UNSPSC :

  12352200

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Amino Acid Derivatives; Biochemical Assay Reagents

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Others

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/n-boc-d-prolinol.html

• Purity :

  99.99

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1[C@H](CCC1)CO)OC(C)(C)C

• Molecular Formula :

  C10H19NO3

• Molecular Weight :

  201.27

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Procopiou PA, et al. The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. J Med Chem. 2011 Apr 14;54 (7) :2183-95. |[2]Procopiou PA, et al. Synthesis and pharmacological investigation of azaphthalazinone human histamine H (1) receptor antagonists. Bioorg Med Chem. 2012 Oct 15;20 (20) :6097-108.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported