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Relamorelin

CAT: 0804-HY-19884Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19884Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research[1][2][3][4].
CAS Number
[661472-41-9]
Product Name Alternative
RM-131; BIM-28131
UNSPSC
12352209
Target
GHSR
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/relamorelin.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCNCC1)N[C@H](CC2=CSC3=CC=CC=C23)C(N[C@@H](C(N[C@@H](CC4=CC=CC=C4)C(NC5(CCNCC5)C(N)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O
Molecular Formula
C43H50N8O5S
Molecular Weight
790.97
References & Citations
[1]DeBoer MD, et, al. Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology. 2007 Jun;148 (6) :3004-12.|[2]Fischer K, et, al. The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor. Front Nutr. 2015 Jan 12;1:31.|[3]Zatorski H, et, al. Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and proton pump inhibitors-resistant non-erosive reflux disease. J Physiol Pharmacol. 2017 Dec;68 (6) :797-805.|[4]Matthew Heckroth, et al. Nausea and Vomiting in 2021: A Comprehensive Update. J Clin Gastroenterol. 2021 Apr 1;55 (4) :279-299.|[5]Victor Chedid, et al. Relamorelin for the treatment of gastrointestinal motility disorders. Expert Opin Investig Drugs. 2017 Oct;26 (10) :1189-1197.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 3

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