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Rebeccamycin

CAT: 0804-HY-19825Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-19825Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II[1][2].
CAS Number
93908-02-2
UNSPSC
12352005
Target
ADC Payload; Antibiotic; Topoisomerase
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rebeccamycin.html
Solubility
10 mM in DMSO
Smiles
O=C(N1)C(C2=C3N([C@@H]([C@@H]([C@@H](O)[C@@H]4OC)O)O[C@@H]4CO)C5=C2C=CC=C5Cl)=C(C(C6=CC=C7)=C3NC6=C7Cl)C1=O
Molecular Formula
C27H21Cl2N3O7
Molecular Weight
570.38
References & Citations
[1]Merchant J, et al. Phase I clinical and pharmacokinetic study of NSC 655649, a rebeccamycin analogue, given in both single-dose and multiple-dose formats. Clin Cancer Res. 2002 Jul;8 (7) :2193-201.|[2]Bush JA, et al. Production and biological activity of rebeccamycin, a novel antitumor agent. J Antibiot (Tokyo) . 1987 May;40 (5) :668-78.|[3]Sánchez C, et al. The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol. 2002 Apr;9 (4) :519-31.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I; Traditional Cytotoxic Agents

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