Rebeccamycin

• Description :

  Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II[1][2].

• CAS Number :

  [93908-02-2]

• UNSPSC :

  12352005

• Target :

  ADC Payload; Antibiotic; Topoisomerase

• Type :

  Natural Products

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rebeccamycin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1)C(C2=C3N([C@@H]([C@@H]([C@@H](O)[C@@H]4OC)O)O[C@@H]4CO)C5=C2C=CC=C5Cl)=C(C(C6=CC=C7)=C3NC6=C7Cl)C1=O

• Molecular Formula :

  C27H21Cl2N3O7

• Molecular Weight :

  570.38

• References & Citations :

  [1]Merchant J, et al. Phase I clinical and pharmacokinetic study of NSC 655649, a rebeccamycin analogue, given in both single-dose and multiple-dose formats. Clin Cancer Res. 2002 Jul;8 (7) :2193-201.|[2]Bush JA, et al. Production and biological activity of rebeccamycin, a novel antitumor agent. J Antibiot (Tokyo) . 1987 May;40 (5) :668-78.|[3]Sánchez C, et al. The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol. 2002 Apr;9 (4) :519-31.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Topo I; Traditional Cytotoxic Agents