A-893

CAT: 0804-HY-19563Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19563Size:1 Each
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Description
A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM.
CAS Number
[1868232-32-9]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-893.html
Solubility
10 mM in DMSO
Smiles
O=C(CCNCCC1=CC(Cl)=C(Cl)C=C1)N(C2CCCCC2)CCNC[C@H](O)C3=CC=CC(N4)=C3OCC4=O
Molecular Formula
C29H38Cl2N4O4
Molecular Weight
577.54
References & Citations
[1]Sweis RF, et al. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6 (6) :695-700.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SMYD2

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