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Apogossypolone

CAT: 0804-HY-19551-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19551-01Size:1 mg
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Description
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis[1] and autophagy[2]. Apogossypolone also has antifungal activity[3].
CAS Number
886578-07-0
Product Name Alternative
ApoG2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Bcl-2 Family; Fungal; ROS Kinase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/apogossypolone.html
Purity
98.58
Solubility
10 mM in DMSO
Smiles
O=C1C(C(C2=O)=C(C)C(C3=C2C=C(O)C(O)=C3C(C)C)=O)=C(C)C(C4=C1C=C(O)C(O)=C4C(C)C)=O
Molecular Formula
C28H26O8
Molecular Weight
490.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuan Sun, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7 (9) :1418-26. |[2]Jay E Mellon, et al. Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi. J Agric Food Chem. 2012 Mar 14;60 (10) :2740-5.|[3]Cheng P, et al. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis. 2013 Feb 7;4 (2) :e489.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL; Mcl-1

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