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Apogossypolone (ApoG2)

CAT: 0931-T21786-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T21786-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
886578-07-0
Target
ROS Kinase, Apoptosis, Bcl-2 Family, Others, Antifungal, Autophagy
Related Pathways
Tyrosine Kinase/Adaptors, Microbiology/Virology, Apoptosis, Others, Autophagy
Bioactivity
Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis [1] and autophagy [2]. Apogossypolone also has antifungal activity [3].
Smiles
C(C)(C)C1=C2C(C(=O)C(=C(C)C2=O)C=3C(=O)C=4C(C(=O)C3C)=C(C(C)C)C(O)=C(O)C4)=CC(O)=C1O
Molecular Formula
C28H26O8
Molecular Weight
490.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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