cis-ACPD

• UNSPSC Description:

  cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

• Target Antigen:

  iGluR; mGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cis-acpd.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@]1(N)C[C@H](C(O)=O)CC1)O

• Molecular Weight:

  173.17

• References & Citations:

  [1]Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56(5):1789-96.|[2]Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57(11): 889-95.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  477331-06-9