Cis-ACPD

• Description :

  Cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H315-H319-H335

• Target :

  IGluR; mGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cis-acpd.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@]1(N)C[C@H](C(O)=O)CC1)O

• Molecular Formula :

  C7H11NO4

• Molecular Weight :

  173.17

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis- (+-) -1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56 (5) :1789-96.|[2]Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57 (11) : 889-95.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR2; mGluR4; NMDA Receptor

• CAS Number :

  [477331-06-9]