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Cis-ACPD

CAT: 0804-HY-19434ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19434ASize:1 Each
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Description
Cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].
CAS Number
477331-06-9
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
IGluR; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cis-acpd.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]1(N)C[C@H](C(O)=O)CC1)O
Molecular Formula
C7H11NO4
Molecular Weight
173.17
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis- (+-) -1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56 (5) :1789-96.|[2]Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57 (11) : 889-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR4; NMDA Receptor

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