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Lactimidomycin

CAT: 0804-HY-18979Size: 200 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-18979Size:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC50 value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities[1][2].
CAS Number
134869-15-1
UNSPSC
12352005
Target
Dengue Virus; Flavivirus
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/lactimidomycin.html
Purity
99.90
Solubility
DMSO : 5.72 mg/mL (ultrasonic; warming)
Smiles
O=C(CC(C[C@@H](O)CC([C@@H](C)/C=C([C@@H]([C@@H](C)/C=C\C=C\CC/C=C/1)OC1=O)\C)=O)C2)NC2=O
Molecular Formula
C26H35NO6
Molecular Weight
457.56
References & Citations
[1]Schneider-Poetsch T, et al. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol. 2010 Mar;6 (3) :209-217.|[2]Carocci M, et al. Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Res. 2016 Apr;128:57-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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