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JI6

CAT: 0804-HY-18949Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18949Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JI6 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ～40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits JAK3 and c-Kit, with IC50s of ～250 and ～500 nM, respectively. JI6 can be used for the research of acute myeloid leukemia[1].
CAS Number
856436-16-3
UNSPSC
12352005
Target
C-Kit; FLT3; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ji6.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC=C(C3=CN=CC=C3)C=C2/C1=C/C4=CC=CN4.O=S(O)(C)=O
Molecular Formula
C19H17N3O4S
Molecular Weight
383.42
References & Citations
[1]Chen Y, et, al. Identification of an orally available compound with potent and broad FLT3 inhibition activity. Oncogene. 2016 Jun 9;35 (23) :2971-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3

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