JI6

CAT: 0013-GTR19213472-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19213472-03Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

JI6 is a potent, selective, and orally bioavailable small molecule inhibitor primarily targeting FLT3 (IC50 ~40 nM WT), with additional activity against c-Kit and JAK3. It is a valuable research tool for studying acute myeloid leukemia, demonstrating efficacy in both cellular assays and in vivo models of FLT3-driven disease.

CAS Number

856436-16-3

Product Name Alternative

JI 6, JI6, JI-6, JAK3 Inhibitor VI, FLT3

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

97.74% (May vary between batches)

Solubility

DMSO:4.5 mg/mL (11.74 mM)

Smiles

CS (=O) (O) =O.O=C (/C1=C\C2=CC=CN2) NC (C=C3) =C1C=C3C4=CN=CC=C4

Molecular Formula

C19H17N3O4S

Molecular Weight

383.42

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

JAK3 inhibitor VI mesylate

CAS Number	856436-16-3
PubChem CID	16760524
IUPAC Name	methanesulfonic acid;(3Z)-5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one
Molecular Formula	C19H17N3O4S
Molecular Weight	383.4
Topological Polar Surface Area	121
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	27
Formal Charge	0
Complexity	554

SMILES

CS(=O)(=O)O.C1=CC(=CN=C1)C2=CC\3=C(C=C2)NC(=O)/C3=C\C4=CC=CN4

InChI

InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;

InChIKey

ZUDPNBZMAJGYTE-HYMQDMCPSA-N

Chemical Structure

2D Structure

CAS: 856436-16-3

CID: 16760524

Formula: C19H17N3O4S

MW: 383.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	383.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	383.09397721
Monoisotopic Mass	383.09397721
Topological Polar Surface Area	121 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	554
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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JI6

Chemical Information

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