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PCS1055

CAT: 0804-HY-122203A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122203A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PCS1055 is a selective and competitive antagonist for muscarinic M4 receptor with an IC50 of 18.1 nM and a Kd of 5.72 nM. PCS1055 inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. PCS1055 is also an inhibitor for AChE with IC50 of 22 nM and 120 nM for electric eel and human AChE, respectively[1][2].
CAS Number
357173-55-8
UNSPSC
12352005
Target
Cholinesterase (ChE) ; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pcs1055.html
Purity
98.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C12=NN=C(NCCC3CCN(CC4=CC=CC=C4)CC3)C=C1CCCC5=CC=CC=C52
Molecular Formula
C27H32N4
Molecular Weight
412.57
References & Citations
[1]Croy CH, et al. Characterization of PCS1055, a novel muscarinic M4 receptor antagonist. Eur J Pharmacol. 2016 Jul 5;782:70-6.|[2]Contreras JM, et al. Design, synthesis, and structure-activity relationships of a series of 3-[2- (1-benzylpiperidin-4-yl) ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors. J Med Chem. 2001 Aug 16;44 (17) :2707-18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; mAChR4
Citation 01
Mol Cell Endocrinol. 2025 Jan 21:599:112464.|Neuron. 2025 Mar 5;113 (5) :670-683.e7.

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