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Carboxy-PTIO

CAT: 0804-HY-18734Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18734Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carboxy-PTIO is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model[1][2][3].
CAS Number
145757-47-7
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/carboxy-ptio.html
Solubility
10 mM in DMSO
Smiles
[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=C(C(O)=O)C=C2
Molecular Formula
C14H17N2O4
Molecular Weight
277.30
References & Citations
[1]Hao He, et al.Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.Food Chem Toxicol. 2014 Sep;71:128-35.|[2]T Akaike, et al. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry. 1993 Jan 26;32 (3) :827-32.|[3]M Yoshid, et al. Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem Biophys Res Commun. 1994 Jul 29;202 (2) :923-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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