Filgotinib-d4

• Description:

  Filgotinib-d4 is the deuterium labeled Filgotinib. Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

• Product Name Alternative:

  GLPG0634-d4

• UNSPSC:

  12352005

• Target:

  JAK

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Purity:

  0.98

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C1C ([2H]) ([2H]) C1 ([2H]) [2H]) NC2=NN3C (C4=CC=C (C=C4) CN5CCS (=O) (CC5) =O) =CC=CC3=N2

• Molecular Formula:

  C21H19D4N5O3S

• Molecular Weight:

  429.53

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Menet CJ, et al. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J Med Chem. 2014 Nov 17.|[3]Van Rompaey L, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013, 191 (7), 3568-3577.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2041095-50-3