Quercetin-d3

• Description :

  Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

• CAS Number :

  [263711-79-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Apoptosis; Autophagy; Isotope-Labeled Compounds; Mitophagy; PI3K; Reactive Oxygen Species (ROS)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Purity :

  98.73

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C(O)=C(C2=C([2H])C(O)=C(O)C([2H])=C2[2H])OC3=CC(O)=CC(O)=C13

• Molecular Formula :

  C15H7D3O7

• Molecular Weight :

  305.25

• Precautions :

  H301

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31 (3) :176-81.|[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10 (5) :e0128277.|[4]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81 (2) :75-80.|[5]Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported