Quercetin

• Description :

  Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Apoptosis; Autophagy; Mitophagy; PI3K; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Quercetin.html

• Purity :

  99.80

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 16.67 mg/mL (ultrasonic)

• Smiles :

  OC1=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1=O

• Molecular Formula :

  C15H10O7

• Molecular Weight :

  302.24

• Precautions :

  H301

• References & Citations :

  [1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81 (2) :75-80.|[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31 (3) :176-81.|[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10 (5) :e0128277.|[4]Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  PI3Kβ; PI3Kγ; PI3Kδ

• Citation 01 :

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• CAS Number :

  [117-39-5]