Pyrimethamine-d3

• Description :

  Pyrimethamine-d3 is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR) [1][2].

• UNSPSC :

  12352005

• Target :

  Antifolate; Isotope-Labeled Compounds; Parasite

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Others

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Purity :

  99.90

• Solubility :

  DMSO : 20 mg/mL (ultrasonic; warming)

• Smiles :

  C(C([2H])([2H])[2H])C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2

• Molecular Formula :

  C12H10D3ClN4

• Molecular Weight :

  251.73

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Basco LK, et al. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50 (2) :193-9.|[3]Inceboz T, et al. Preparation of (131) I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infectedrats. J Drug Target. 2013 Feb;21 (2) :175-9.|[4]Wright PD, et al. Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models. Neurosci Lett. 2010 Oct 4;482 (3) :188-92.|[5]Martins-Duarte ES, et al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133 (3) :294-9.|[6]Taylor WR, et al. Antimalarial drug toxicity: a review. Drug Saf. 2004;27 (1) :25-61.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1189936-99-9]