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Pyrimethamine-d3

CAT: 0804-HY-18062SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18062SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyrimethamine-d3 is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR) [1][2].
CAS Number
1189936-99-9
UNSPSC
12352005
Target
Antifolate; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
99.90
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
C(C([2H])([2H])[2H])C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2
Molecular Formula
C12H10D3ClN4
Molecular Weight
251.73
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Basco LK, et al. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb; 50 (2) :193-9.|[3]Inceboz T, et al. Preparation of (131) I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infectedrats. J Drug Target. 2013 Feb;21 (2) :175-9.|[4]Wright PD, et al. Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models. Neurosci Lett. 2010 Oct 4;482 (3) :188-92.|[5]Martins-Duarte ES, et al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133 (3) :294-9.|[6]Taylor WR, et al. Antimalarial drug toxicity: a review. Drug Saf. 2004;27 (1) :25-61.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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