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Pyrimethamine

CAT: 0804-HY-18062-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18062-01Size:100 mg
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Description
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate[1][2].
CAS Number
[58-14-0]
Product Name Alternative
Pirimecidan; Pirimetamin; RP 4753
UNSPSC
12352005
Hazard Statement
H302
Target
Antifolate; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/pyrimethamine.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1
Molecular Formula
C12H13ClN4
Molecular Weight
248.71
Precautions
H302
References & Citations
[1]Aikawa M, et, al. Studies on nuclear division of a malarial parasite under pyrimethamine treatment. J Cell Biol. 1968 Dec;39 (3) :749-54.|[2]Martins-Duarte ÉS, et, al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133 (3) :294-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium

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