Clarithromycin-d3

Clarithromycin-d3

• CAS Number: 959119-22-3
• UNSPSC Description: Clarithromycin-d3 is the deuterium labeled Clarithromycin (HY-17508)[1]. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[3]. Clarithromycin significantly inhibits the HERG potassium current[4].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[5].
• Target Antigen: Antibiotic; Autophagy; Bacterial; Cytochrome P450; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Autophagy;Metabolic Enzyme/Protease;Others
• Field of Research: Others
• Purity: 97.34
• Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming)
• Smiles: C[C@@](OC)(C[C@H](C([C@@H]1C)=O)C)[C@@H]([C@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@@H]1O)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)C)O[C@@](O[C@H](C)C[C@@H]3N(C([2H])([2H])[2H])C)([H])[C@@H]3O
• Molecular Weight: 750.97
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: No Development Reported