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Clarithromycin-d3

CAT: 0804-HY-17508S1Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17508S1Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clarithromycin-d3 is the deuterium labeled Clarithromycin. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[3]. Clarithromycin significantly inhibits the HERG potassium current[4].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[5].
CAS Number
959119-22-3
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Autophagy; Bacterial; Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Others
Purity
99.90
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming)
Smiles
C[C@@](OC)(C[C@H](C([C@@H]1C)=O)C)[C@@H]([C@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@@H]1O)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)C)O[C@@](O[C@H](C)C[C@@H]3N(C([2H])([2H])[2H])C)([H])[C@@H]3O
Molecular Formula
C38H66D3NO13
Molecular Weight
750.97
Precautions
H302
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

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AR-C03022-01Clarithromycin-13C-d3
CS-O-06492Clarithromycin-13C, d3
RM-C181334-01Clarithromycin-N-Methyl-D3
CS-T-94841Clarithromycin N-Methyl-13C, d3
CS-P-0272714-Hydroxy clarithromycin-13C-d3
sc-48276112-O-Methyl Clarithromycin-d3
TRC-C559754-10MGClarithromycin-N-methyl-13C, d3
CS-O-45303Clarithromycin-N-methyl-13C-D3
AR-C05374-01(14R) 14-Hydroxy Clarithromycin-13C-d3
C5829-01Clarithromycin-N-methyl-d3 (6-O-Methylerythromycin-N-methyl-d3)

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