Clarithromycin

• Description:

  Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[2]. Clarithromycin significantly inhibits the HERG potassium current[3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Antibiotic; Autophagy; Bacterial; Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Autophagy; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Clarithromycin.html

• Purity:

  99.90

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  C[C@@](OC)(C[C@H](C([C@@H]1C)=O)C)[C@@H]([C@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@@H]1O)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)([H])[C@@H]3O

• Molecular Formula:

  C38H69NO13

• Molecular Weight:

  747.95

• Precautions:

  H302

• References & Citations:

  Mycobacterium avium

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  CYP3; Macrolide

• CAS Number:

  [81103-11-9]