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Sancycline (hydrochloride)

CAT: 0804-HY-17466ASize: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17466ASize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline. Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].
CAS Number
6625-20-3
Product Name Alternative
Bonomycin (hydrochloride) ; 6-Demethyl-6-deoxytetracycline (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sancycline-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C1=C([C@H]([C@@]([H])([C@]2(C1=O)O)C[C@]3(C(C(C4=C(C=CC=C4C3)O)=O)=C2O)[H])N(C)C)O.Cl
Molecular Formula
C21H23ClN2O7
Molecular Weight
450.87
Precautions
H302, H315, H319, H335
References & Citations
[1]Li G, et al. A brief overview of classical natural product drug synthesis and bioactivity[J]. Organic Chemistry Frontiers, 2022, 9 (2) : 517-571.|[2]Gordon MK, et al. Doxycycline hydrogels as a potential therapy for ocular vesicant injury[J]. J Ocul Pharmacol Ther. 2010 Oct;26 (5) :407-19. |[3]Nikita Shanmugam, et al. Abraham solvation parameter model: determination of experiment-based solute descriptor values for 3,5-dimethoxybenzoic acid based on measured solubility data[J]. Physics and Chemistry of Liquids. 2024. 62: 2: 89-100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tetracycline

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