Products for Research Use Only
RegisterLogin

Fenofibrate (GMP)

CAT: 0804-HY-17356GSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-17356GSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Fenofibrate (GMP) is Fenofibrate produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
CAS Number
49562-28-9
UNSPSC
12352005
Hazard Statement
H373
Target
Autophagy; Cytochrome P450; PPAR
Type
GMP Small Molecules
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fenofibrate-gmp.html
Solubility
10 mM in DMSO
Smiles
CC(C)(OC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1)C(OC(C)C)=O
Molecular Formula
C20H21ClO4
Molecular Weight
360.83
Precautions
P260-P501
References & Citations
[1]Schelleman H, et al. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78 (3) :639-48.|[2]Gong Y, et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Sep 30. pii: S2352-3964 (16) 30448-0.|[3]Binello E, et al. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells. J Neurooncol. 2014 Apr;117 (2) :225-34./|[4]Sun C, et al. Duchenne muscular dystrophy hiPSC-derived myoblast drug screen identifies compounds that ameliorate disease in mdx mice. JCI Insight. 2020 Jun 4;5 (11) :e134287.|[5]Lojewski X, et al. Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Hum Mol Genet. 2014 Apr 15;23 (8) :2005-22.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

Related Products

CatalogName
HY-17356-01Fenofibrate
HY-14739-01Choline Fenofibrate
HY-17356SFenofibrate-d6
HY-17356R-01Fenofibrate (Standard)
HY-17356S1Fenofibrate-d4
HY-17356S2Fenofibrate-13C6
HY-14739R-01Choline Fenofibrate (Standard)
HY-10219G-01Rapamycin (GMP)
HY-N0737AG-01Harmine (GMP)
HY-N0083GBetulin (GMP)

Alternative Products

CatalogName
B1943-10000Fenofibrate

Popular Products