SARS-CoV-2-IN-77

• UNSPSC Description:

  SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity[1].

• Target Antigen:

  Cathepsin; SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sars-cov-2-in-77.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C#N)=O)NC(COC2=C(C=C(C=C2)Cl)Cl)=O)C

• Molecular Weight:

  462.37

• References & Citations:

  [1]Philipp Flury, et al. Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS Pharmacol. Transl. Sci. January 19, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported