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SARS-CoV-2-IN-77

CAT: 0804-HY-163206Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163206Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity[1].
UNSPSC
12352005
Target
Cathepsin; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-in-77.html
Solubility
10 mM in DMSO
Smiles
CC(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C#N)=O)NC(COC2=C(C=C(C=C2)Cl)Cl)=O)C
Molecular Formula
C23H25Cl2N3O3
Molecular Weight
462.37
References & Citations
[1]Philipp Flury, et al. Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS Pharmacol. Transl. Sci. January 19, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin L; Cathepsin S

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