Microcolin H

Microcolin H

• CAS Number: 2408008-21-7
• UNSPSC Description: Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models[1].
• Target Antigen: Atg8/LC3; Autophagy; p62
• Type: Natural Products
• Related Pathways: Autophagy
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/microcolin-h.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O
• Molecular Weight: 733.93
• References & Citations: [1]Yang H et al. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Signal Transduct Target Ther. 2023 Nov 15;8(1):428.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported