Microcolin H

CAT: 0804-HY-163001-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-163001-01Size:1 mg
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Description
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy) . Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models[1].
CAS Number
[2408008-21-7]
UNSPSC
12352209
Target
Atg8/LC3; Autophagy; p62
Type
Natural Products
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microcolin-h.html
Purity
99.13
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O
Molecular Formula
C38H63N5O9
Molecular Weight
733.93
References & Citations
[1]Yang H et al. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Signal Transduct Target Ther. 2023 Nov 15;8 (1) :428.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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