Microcolin H

• Description :

  Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy) . Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models[1].

• UNSPSC :

  12352209

• Target :

  Atg8/LC3; Autophagy; p62

• Type :

  Natural Products

• Related Pathways :

  Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/microcolin-h.html

• Purity :

  99.13

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O

• Molecular Formula :

  C38H63N5O9

• Molecular Weight :

  733.93

• References & Citations :

  [1]Yang H et al. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Signal Transduct Target Ther. 2023 Nov 15;8 (1) :428.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [2408008-21-7]