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Lecimibide

CAT: 0804-HY-16281Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16281Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research[1][2].
CAS Number
130804-35-2
Product Name Alternative
DuP 128
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lecimibide.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
Molecular Formula
C34H40F2N4OS
Molecular Weight
590.77
References & Citations
[1]L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42 (5) :725-34. |[2]J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393 (1) :63-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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