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PfThrRS-IN-1

CAT: 0804-HY-162072Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162072Size:1 Each
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Description
PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC50 value of 0.1 μM. PfThrRS-IN-1 is a potent antimalaria agent[1].
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfthrrs-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](O)[C@H](N)C(NS(=O)(C1=NC2=CC(C3=NC=NC(N)=C3)=CC=C2S1)=O)=O
Molecular Formula
C15H16N6O4S2
Molecular Weight
408.46
References & Citations
[1]Jekaterina Bolsakova, et al. Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library. December 2023 ACS Medicinal Chemistry Letters
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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