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KRAS G12D modulator-1

CAT: 0804-HY-153555Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153555Size:1 Each
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Description
KRAS G12D modulator-1 (compound 6) is a potent KRAS G12D modulator with IC50 values of 1-10 μM for NEA-G12D, PPI-G12D, and p ERK-AGS, respectively. KRAS G12D modulator-1 can be used in research of cancer[1].
CAS Number
2883034-05-5
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12d-modulator-1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC(C=CC=C2)=C2C(N3CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7C[C@@H](C[C@H](C7)O)O)=C4CC3)=C1
Molecular Formula
C30H36FN5O4
Molecular Weight
549.64
References & Citations
[1]Hong L, et, al. Kras modulators and uses thereof. WO2022261210.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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