SrtA-IN-2

• Description :

  SrtA-IN-2 (compound Y40), a ML346 (HY-18669) analog, is a Sortase A (SrtA) inhibitor. SrtA-IN-2 shows inhibitory activity on Staphylococcus aureus SrtA and shows inhibitory effects on biofilm formation. SrtA-IN-2 is an antivirulence agent against S. aureus infections[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/antibacterial-agent-175.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(/C1=C\C=C\C2=CC=C(C=C2)OCC3=CC=C(C=C3)F)NC(NC1=O)=O

• Molecular Formula :

  C20H15FN2O4

• Molecular Weight :

  366.34

• References & Citations :

  [1]Chuan Yue, et al. Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent Staphylococcus aureus Sortase A Inhibitors. J Med Chem. 2024 Jan 3.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [9007-83-4]