SRT 2104

CAT: 0804-HY-15262-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15262-01Size:5 mg
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Description
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease[1][2][3].
CAS Number
[1093403-33-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/SRT-2104.html
Purity
99.27
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4
Molecular Formula
C26H24N6O2S2
Molecular Weight
516.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Hoffmann E, et al. Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.|[2]Jiao D, et al. MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. J Mol Med (Berl) . 2018 Sep;96 (9) :939-949.|[3]Jiang M, et al. Sirtuin 1 activator SRT2104 protects Huntington's disease mice. Ann Clin Transl Neurol. 2014 Dec;1 (12) :1047-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
SIRT1

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