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Drpitor1a

CAT: 0804-HY-161119-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-161119-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer[1][2].
CAS Number
73326-98-4
UNSPSC
12352005
Target
Dynamin; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/drpitor1a.html
Purity
96.95
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(C=CC=C3)=C3N2)C(C4=CN=CC=C41)=O
Molecular Formula
C15H8N2O2
Molecular Weight
248.24
References & Citations
[1]Wu D, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 Jan;34 (1) :1447-1464. |[2]Wu D, et al. Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572836.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione
CAS Number73326-98-4
PubChem CID343549
IUPAC Name6H-pyrido[4,3-b]carbazole-5,11-dione
Molecular FormulaC15H8N2O2
Molecular Weight248.24
XLogP2.3
Topological Polar Surface Area62.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count19
Formal Charge0
Complexity422
SMILES
C1=CC=C2C(=C1)C3=C(N2)C(=O)C4=C(C3=O)C=NC=C4
InChI
InChI=1S/C15H8N2O2/c18-14-10-7-16-6-5-8(10)15(19)13-12(14)9-3-1-2-4-11(9)17-13/h1-7,17H
InChIKey
KPOPOVJXCUAKLY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione
CAS: 73326-98-4
CID: 343549
Formula: C15H8N2O2
MW: 248.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight248.24
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass248.058577502
Monoisotopic Mass248.058577502
Topological Polar Surface Area62.8 Ų
Heavy Atom Count19
Formal Charge0
Complexity422
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA4573-25Drpitor1a

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