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Drpitor1a

CAT: 0804-HY-161119-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161119-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer[1][2].
CAS Number
73326-98-4
UNSPSC
12352005
Target
Dynamin; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/drpitor1a.html
Purity
96.95
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(C=CC=C3)=C3N2)C(C4=CN=CC=C41)=O
Molecular Formula
C15H8N2O2
Molecular Weight
248.24
References & Citations
[1]Wu D, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 Jan;34 (1) :1447-1464. |[2]Wu D, et al. Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572836.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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