Apalutamide-d3

CAT: 0804-HY-16060S1-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16060S1-01Size:1 mg
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Description
Apalutamide-d3 is the deuterium labeled Apalutamide[1]. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[2].
CAS Number
[1638885-61-6]
Product Name Alternative
ARN-509-d3
UNSPSC
12352005
Target
Androgen Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1C2(CCC2)N(C3=CC(F)=C(C=C3)C(NC([2H])([2H])[2H])=O)C(N1C4=CN=C(C#N)C(C(F)(F)F)=C4)=S
Molecular Formula
C21H12D3F4N5O2S
Molecular Weight
480.45
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15;72 (6) :1494-503.|[3]Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838 (16) 30133
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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