K2-B4-3e

• UNSPSC Description:

  K2-B4-3e is a potent BRD4 PROTAC. K2-B4-3e induces BRD4 degradation with a DC50 value of 66 nM[1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/k2-b4-3e.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC(C1=CC2=C(N(C1=O)C3=CN(C(C=C3)=O)CC(OC)=O)CN(CC2)C(OCCC4CCN(CC4)CC5CCN(CC5)C(C[C@@H]6N=C(C7=C(N8C(C)=NN=C68)SC(C)=C7C)C9=CC=C(C=C9)Cl)=O)=O)C

• Molecular Weight:

  1006.65

• References & Citations:

  [1]Hickey CM, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat Struct Mol Biol. 2024 Jan 4.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported