K2-B4-3e

• Description :

  K2-B4-3e is a potent BRD4 PROTAC. K2-B4-3e induces BRD4 degradation with a DC50 value of 66 nM[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/k2-b4-3e.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCC(C1=CC2=C(N(C1=O)C3=CN(C(C=C3)=O)CC(OC)=O)CN(CC2)C(OCCC4CCN(CC4)CC5CCN(CC5)C(C[C@@H]6N=C(C7=C(N8C(C)=NN=C68)SC(C)=C7C)C9=CC=C(C=C9)Cl)=O)=O)C

• Molecular Formula :

  C53H64ClN9O7S

• Molecular Weight :

  1006.65

• References & Citations :

  [1]Hickey CM, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat Struct Mol Biol. 2024 Jan 4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported