K2-B4-5e

• UNSPSC Description:

  K2-B4-5e is a E3 ligase KLHDC2-based BRD4 and androgen receptor (AR) degradation PROTAC. K2-B4-5e is capable of inducing rapid and robust degradation of BET-family and AR proteins in cells[1].

• Target Antigen:

  Androgen Receptor; Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/k2-b4-5e.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C[C@@H]1N=C(C2=C(N3C(C)=NN=C13)SC(C)=C2C)C4=CC=C(C=C4)Cl)NC5=CC=C(C=C5)C6=CC=C(C=C6)C(N7CCC8=C(N(C(C(CC(C)C)=C8)=O)C9=CN(C(C=C9)=O)CC(OC)=O)C7)=O

• Molecular Weight:

  949.51

• References & Citations:

  [1]Christopher M Hickey, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat Struct Mol Biol. 2024 Jan 4.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported