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LAH-1

CAT: 0804-HY-157519Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157519Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LAH-1 is a c-Met inhibitor with oral activity and membrane permeability with an IC50 of 49 nM. LAH-1 has anticancer activity and can induce apoptosis, migration, and invasion[1].
CAS Number
[3018150-68-7]
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lah-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C(C)=C1)=NN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC(NC(N5CC(O)C5)=O)=NC=C4)C(F)=C3
Molecular Formula
C27H22F2N6O5
Molecular Weight
548.50
References & Citations
[1]Sima L, et al. Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39 (1) : 2286435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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