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Dobutamine (tartrate)

CAT: 0804-HY-15746BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15746BSize:1 Each
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Description
Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors) . Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion[1][2][3][4].
CAS Number
101626-66-8
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/dobutamine-tartrate.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.O=C(O)[C@@H](O)[C@H](O)C(O)=O
Molecular Formula
C22H29NO9
Molecular Weight
451.47
References & Citations
[1]Tuttle RR, et al. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975 Jan;36 (1) :185-96.|[2]Vallet B, et al. Dobutamine: mechanisms of action and use in acute cardiovascular pathology. Ann Cardiol Angeiol (Paris) . 1991 Jun;40 (6) :397-402.|[3]Tyrankiewicz U , et al. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013 Mar;37 (3) :669-77.|[4]Tibayan FA, et al. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156 (2 Pt 1) :438-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor; β adrenergic receptor

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