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JAK-IN-34

CAT: 0804-HY-157121Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157121Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK-IN-34 (compound 11n) is a potent against of JAKs with IC50 values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety[1].
CAS Number
2068766-90-3
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak-in-34.html
Solubility
10 mM in DMSO
Smiles
N#CCOC1=CC=C(C2=CC=CC3=C2N=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3)C=C1
Molecular Formula
C27H26N6O
Molecular Weight
450.53
References & Citations
[1]Jinbao Xiang, et al. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors. Bioorg Chem. 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3; Tyk2

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