JAK-IN-34

• UNSPSC Description:

  JAK-IN-34 (compound 11n) is a potent against of JAKs with IC50 values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety[1].

• Target Antigen:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jak-in-34.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CCOC1=CC=C(C2=CC=CC3=C2N=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3)C=C1

• Molecular Weight:

  450.53

• References & Citations:

  [1]Jinbao Xiang, et al. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors. Bioorg Chem. 2023.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2068766-90-3