ICMT-IN-48

• Description:

  ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1xKm SAM) and 2.3 μM (10xKm SAM), respectively[1].

• UNSPSC:

  12352005

• Target:

  ICMT

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/icmt-in-48.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C(C2CC(C)(C)OCC2)CCN(C(C3=CC=CO3)=O)CC4=CC=C(OC)C=C4)C=CC=C1

• Molecular Formula:

  C30H37NO5

• Molecular Weight:

  491.62

• References & Citations:

  [1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) . J Med Chem. 2011 Jul 28;54 (14) :5031-47.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [337486-54-1]