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ICMT-IN-48

CAT: 0804-HY-157116Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157116Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1xKm SAM) and 2.3 μM (10xKm SAM), respectively[1].
CAS Number
337486-54-1
UNSPSC
12352005
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-48.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C(C2CC(C)(C)OCC2)CCN(C(C3=CC=CO3)=O)CC4=CC=C(OC)C=C4)C=CC=C1
Molecular Formula
C30H37NO5
Molecular Weight
491.62
References & Citations
[1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) . J Med Chem. 2011 Jul 28;54 (14) :5031-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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