DDa-1

• Description:

  DDa-1 is a potent BTK degrader (DC50: 90 nM) . Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BTK ligand (HY-107447) [1].

• UNSPSC:

  12352005

• Target:

  Btk; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dda-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CCN(C2=CC=C3C(N=C(C4(C5=CC=C(Cl)C=C5)CCCCC4)N=C3NCCN)=C2)CC1)CCCCCCCN6CCC(OC7CCN(C8=CC(NC9=NC=C(C(NC%10=C(C)C=CC=C%10Cl)=O)S9)=NC(C)=N8)CC7)CC6

• Molecular Formula:

  C60H77Cl2N13O3S

• Molecular Weight:

  1131.31

• References & Citations:

  [1]Schröder M, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15 (1) :275.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3036944-98-3]