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ICMT-IN-1

CAT: 0804-HY-156500-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156500-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ICMT-IN-1 is a potent inhibitor of ICMT with an IC50 of 1.3 nM. ICMT-IN-1 can delay senescence and stimulate late-passage HGPS cells and Zmpste24-deficient mouse fibroblasts proliferation[1].
CAS Number
1313603-22-3
UNSPSC
12352005
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C1)OC(C)(C)CC1(C2=CC=CC=C2)CCNC3=CC(OC)=CC=C3
Molecular Formula
C24H33NO2
Molecular Weight
367.52
References & Citations
[1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) . J Med Chem. 2011 Jul 28;54 (14) :5031-47.|[2]Chen X, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. Elife. 2021 Feb 2;10:e63284.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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