PAK4-IN-3

• Description:

  PAK4-IN-3 (compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; PAK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pak4-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O

• Molecular Formula:

  C21H22ClN7O

• Molecular Weight:

  423.90

• References & Citations:

  [1]Han W, et al. Design, synthesis and anticancer activity evaluation of 4- (3-1H-indazolyl) amino quinazoline derivatives as PAK4 inhibitors [published online ahead of print, 2023 Oct 13]. Bioorg Med Chem. 2023;95:117501.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported