PAK4-IN-3

PAK4-IN-3

• UNSPSC Description: PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1[1].
• Target Antigen: Apoptosis; PAK
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pak4-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O
• Molecular Weight: 423.90
• References & Citations: [1]Han W, et al. Design, synthesis and anticancer activity evaluation of 4-(3-1H-indazolyl)amino quinazoline derivatives as PAK4 inhibitors [published online ahead of print, 2023 Oct 13]. Bioorg Med Chem. 2023;95:117501.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported