PAK4-IN-1

• Description:

  PAK4-IN-1 (Compound 19) is a potent, selective, orally active PAK4 inhibitor with robust anti-tumor efficacy in vivo. PAK4-IN-1 is stable under both acidic and neutral conditions[1].

• UNSPSC:

  12352005

• Target:

  PAK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pak4-in-1-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OCOC(C(C)C)=O)N1[C@@H](CN(CC1)C(C2=NC(NC3=NNC(C4CC4)=C3)=C5C=C(C=CC5=N2)Cl)=O)C

• Molecular Formula:

  C26H30ClN7O5

• Molecular Weight:

  556.01

• References & Citations:

  [1]Jing Guo, et al. Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor. Eur J Med Chem. 2020 Jan 15;186:111878.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PAK4

• CAS Number:

  2396529-58-9