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PDE11A4-IN-1

CAT: 0804-HY-156434Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156434Size:1 Each
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Description
PDE11A4-IN-1 (compound 23b) is a potent and selective PDE11A4 inhibitor with an IC50 of 12 nM. PDE11A4-IN-1 show high selectivity for PDE11A4 over PDE1, PDE2, PDE7, PDE8, and PDE9[1].
CAS Number
3027607-92-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pde11a4-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C(N(N=C2C(F)F)C3=CC=CC=C3)=NC(C4=CC=NN4C)=C1)N(CC)CC
Molecular Formula
C22H22F2N6O
Molecular Weight
424.45
References & Citations
[1]Shams Ul Mahmood, et al. First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline. J Med Chem. 2023 Oct 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE11

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