PK-10

• UNSPSC Description:

  PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction[1].

• Target Antigen:

  Fungal; Mitochondrial Metabolism

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/pk-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C(N2CCN(CC2)CC3=CC=C(C(F)(F)F)C=C3)C=C1)/C=C/C4=CC5=C(N=C4N6CCN(CC6)C)C=CC=C5

• Molecular Weight:

  599.69

• References & Citations:

  [1]Sun A, et al. Optimization and antifungal activity of quinoline derivatives linked to chalcone moiety combined with FLC against Candida albicans. Eur J Med Chem. 2023 Nov 15;260:115782.. .

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported